NUMERO: #20241029

Título: A POTENTIAL SUBSTITUTE FOR BONE REPAIR OSTEOPOROTIC PATIENTS INVOLVING DRUG DELIVERY ASSOCIATED WITH BIOMATERIAL 3D.

Nome do Apresentador: Marilia Nanni VIEIRA

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Áreas afins no caráter multidisciplinar

Resumo: Osteoporosis is a disease that affects bone metabolism, resulting bone mass loss and bone fragility. Alternative approaches are sought to accelerate bone repair in these patients. The aim of this study was to evaluate the influence of drug delivery systems using hydrogels incorporated with bioactive glass particles functionalized with strontium ranelate 3D on the formation of mineralization nodules in mesenchymal cells from ovariectomized rat femurs.After two weeks of ovariectomy, the rats were euthanized and the cells were isolated. Subsequently, cells were cultured for 14 days in the following groups: Pure Hydrogel, Hydrogel with Bioactive Glass, and Hydrogel with Strontium Ranelate. The mineralization nodule formation test was then performed.The results demonstrated mineralization nodule formation in all evaluated groups, indicating cellular differentiation towards bone formation. However, a statistically significant difference was observed between the Pure Hydrogel (HP) group and the Hydrogel with Strontium Ranelate (HbSr) group, suggesting that functionalization with strontium ranelate may positively influence bone formation.Although the results are promising, further tests will be necessary to validate and deepen these findings. This study highlights the potential of drug delivery systems using hydrogels incorporated with functionalized bioactive glass particles as a therapeutic strategy to promote bone repair in conditions such as osteoporosis.

Autor 1:  Marilia Nanni VIEIRA

E-mail 1:  [email protected]

Autor 2:   Letícia Adrielly Dias GRISANTE

E-mail 2:  [email protected]

Autor 3 :  Elisa Freire Sant Anna de OLIVEIRA

E-mail 3:  [email protected]

Autor 4:  Juliani Caroline Ribeiro De Araújo SOUTO

E-mail 4:  [email protected]

Autor 5:  Leonardo Alvares Sobral SILVA

E-mail 5:  [email protected]

Autor 6:  Tiago Moreira BASTOS CAMPOS

E-mail 6:  [email protected]

Autor 7:  Luana Marotta Reis de VASCONCELLOS

E-mail 7:  [email protected]