NUMERO: #20240993

Título: Tyrosine kinase inhibitor as a cause of palatal pigmentation.

Nome do Apresentador: André Luis Santana de FREITAS

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: Imatinib is a tyrosine kinase inhibitor drug widely used in the treatment of patients diagnosed with chronic myeloid leukemia and some gastrointestinal tumors. We report the case of a 56-year-old female patient, caucasian, who has been taking Imatinib for 11 years as therapy for previously diagnosed chronic myeloid leukemia. Upon intraoral physical examination, an extensive, asymptomatic blue-grey pigmentation was observed on the hard palate, which was subjected to an incisional biopsy. The biopsy revealed a lamina propria composed of dense connective tissue, brownish pigments, and a granular appearance interspersed with collagen fiber, in intimate contact with fusiform and dendritic cells. The patient was informed about the diagnosis and that treatment is not required.

Autor 1:  André Luis Santana de FREITAS

E-mail 1:  [email protected]

Autor 2:   Marcelo SPERANDIO

E-mail 2:  [email protected]

Autor 3 :  Rosane Rezende de Souza GIULIANI

E-mail 3:  [email protected]

Autor 4:  Alvaro Luiz Mendonça Pinheiro BARBOSA

E-mail 4:  [email protected]

Autor 5:  Tiago TAVARES

E-mail 5:  [email protected]

Autor 6:  Andresa Borges SOARES

E-mail 6:  [email protected]

Autor 7:  Fabricio PASSADOR-SANTOS

E-mail 7:  [email protected]