NUMERO: #20240886

Título: CANNABINOIDS AS A THERAPEUTIC OPTION FOR CONTROLLING RADIO-INDUCED ORAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCER

Nome do Apresentador: Raquel Barbosa PIRES-LOHR

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Objective: To investigate the use of cannabinoids (CBD), associated or not with photobiomodulation (PBM), in the control of oral mucositis (OM).
Study Design: This was a randomized crossover clinical trial with 36 patients with head and neck cancer submitted to radiotherapy (RT). Treatment combinations were administered in randomized order using a Williams design: (A) PBM alone; (B) CBD alone; and (C) combined PBM+CBD. Each intervention was applied at 10 RT sessions. The OM severity (WHO and NCI), oral health-related quality of life (OHIP-14), (MMAS-8) were assessed at RT 0, 10th, 20th, and 30th sessions.
Results: The OM evaluation by the WHO scale showed similar results between groups. The NCI scale showed that the association PBM+CBD presented a lower degree of OM at the 20th RT. At the 30th RT, the association PBM+CBD presented a lower OHIP-14 score when compared to the PBM and CBD alone. The Morisky evaluation showed good adherence to the interventions adopted in all periods evaluated.
Conclusion: The association of CBD and PBM presented less degree of OM at the 20th RT session, and a better oral health-related quality of life at the 30th RT session. The interventions were well tolerated by the participants.

Autor 1:  Raquel Barbosa PIRES-LOHR

E-mail 1:  [email protected]

Autor 2:   Claúdio Rodrigues Leles

E-mail 2:  [email protected]

Autor 3 :  Allisson Filipe Lopes Martins

E-mail 3:  [email protected]

Autor 4:  Diego Antônio Costa Arantes

E-mail 4:  [email protected]

Autor 5:  Marilia Oliveira Morais

E-mail 5:  [email protected]

Autor 6:  Nilceana Maya Aires Freitas

E-mail 6:  [email protected]

Autor 7:  Elismauro Francisco de Mendonça

E-mail 7:  [email protected]