NUMERO: #20240832

Título: MULTISYSTEMIC PRESENTATION OF LANGERHANS CELL HISTIOCYTOSIS IN PEDIATRIC PATIENT: A CASE REPORT OF LETTERER-SIWE DISEASE

Nome do Apresentador: Larissa Santos Amaral ROLIM

Categoria do Trabalho: Apresentação oral de casos clínicos (AOC)

Área Temática: Estomatologia

Resumo: Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. Here we report a case affecting a 1-year-old white male, presented with a complaint of non-healing gingival lesion. Medical history revealed a supposed milk protein allergy, gastric reflux, anorexia, recent fever, and seborrheic dermatitis. On extraoral physical examination, palpable bilateral anterior and post-auricular cervical lymph nodes were noted, along with abdominal distension, fever, and seborrheic dermatitis. Intraoral examination revealed bilateral gingival enlargement in the posterior tooth region. Subsequently, an incisional biopsy of the gingival lesion revealed ulcerative areas with intense mixed inflammatory infiltrate. Immunohistochemical evaluation confirmed positivity for CD1a, CD68, S100, Myeloperoxidase, CD20, and CD3, confirming the diagnosis of Langerhans cell histiocytosis. Due to multisystemic presentation, the diagnosis of Letterer-Siwe disease was confirmed, and the patient was referred for chemotherapeutic treatment being under follow-up.

Autor 1:  Larissa Santos Amaral ROLIM

E-mail 1:  [email protected]

Autor 2:   Helder Domiciano Dantas MARTINS

E-mail 2:  [email protected]

Autor 3 :  Eduarda Gomes Onofre de ARAÚJO

E-mail 3:  [email protected]

Autor 4:  Keila Martha Amorim BARROSO

E-mail 4:  [email protected]

Autor 5:  Ana Carolina Lyra de ALBUQUERQUE

E-mail 5:  [email protected]

Autor 6:  Alexandre Rolim da PAZ

E-mail 6:  [email protected]

Autor 7:  Paulo Rogério Ferreti BONAN

E-mail 7:  [email protected]