NUMERO: #20240793

Título: ACANTHOSIS NIGRICANS: ORAL AND SKIN MANIFESTATIONS ASSOCIATED WITH GASTRIC ADENOCARCINOMA

Nome do Apresentador: Geovana Martins Lopes

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: Acanthosis nigricans is characterized by papillation of the mucosa and skin, hyperkeratosis, and hyperpigmentation. We describe a 46-year-old female patient with poor differentiated gastric adenocarcinoma with multiple metastasis showed multifocal oral lesions characterized by hyperpigmented velvety/warty plaques of pink coloration spongy to palpation throughout the extent of the upper and lower lips, hypochromic velvety/warty plaques on bilateral buccal mucosa and gum with oedema sensitive to touch with a velvety/warty appearance. In association with the lesions in the mouth, the patient presented dark lesions with a rough surface in the armpits, back, abdomen, and face reaching the diagnosis of Leser-Trèlat sign. Associating the type of tumor and the alterations observed in the physical examination, the diagnosis was acanthosis nigricans as a paraneoplastic syndrome. Patients presenting with these dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy, until proven otherwise.

Autor 1:  Geovana Martins Lopes

E-mail 1:  [email protected]

Autor 2:   Victor Tieghi Neto

E-mail 2:  [email protected]

Autor 3 :  Fernando Ernesto Cruz Felippe

E-mail 3:  [email protected]

Autor 4:  José Maria dos Santos Júnior

E-mail 4:  [email protected]

Autor 5:  Alejandro Delfos Hermoza

E-mail 5:  [email protected]

Autor 6:  Fabio Luiz Coracin

E-mail 6:  [email protected]

Autor 7:  Vivian Palata Viola

E-mail 7:  [email protected]