NUMERO: #20240786

Título: EPSTEIN-BARR VIRUS-POSITIVE MUCOCUTANEOUS ULCER: CASE REPORT

Nome do Apresentador: Mariana Andrade COSTA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a proliferative B-cell disorder with isolated lesions on the mucosal tissues. Associated with immunosuppression, such as use of methotrexate. The prognosis is favorable and screening for large B-cell lymphoma requests a multidisciplinary approach. A 69-year-old female patient treating Clippers Syndrome with methotrexate complaining pain in the oral cavity. Examination showed multiple necrotic ulcers with flat edges and erythematous halo in different regions of keratinized mucosa. Incisional biopsies were performed for histopathological analysis, bacterial and fungal cultures and viral PCR. Cultures were not conclusive. The PCR was positive for EBV. Therefore, a blood PCR was requested which was also positive for EBV. Immunohistochemical study and in situ hybridization for atypical lymphoid cells was positive for EBV. The diagnostic conclusion was EBVMCU, without lymphoma signals until now. Methotrexate was discontinued and there has been observed improvement of oral lesions and pain, but no complete resolution.

Autor 1:  Mariana Andrade COSTA

E-mail 1:  [email protected]

Autor 2:   Gabriela da Silva DELADO

E-mail 2:  [email protected]

Autor 3 :  Ana Laura Polizel Ranieri CUNHA

E-mail 3:  [email protected]

Autor 4:  Tatiane Cristina FERRARI

E-mail 4:  [email protected]

Autor 5:  Rodrigo Braz CAMPOS

E-mail 5:  [email protected]

Autor 6:  Lara Maria Alencar Ramos INNOCENTINI

E-mail 6:  [email protected]

Autor 7:  Leandro Dorigan DE MACEDO

E-mail 7:  [email protected]