NUMERO: #20240660

Título: DIFFUSE LARGE B - CELL LYMPHOMA WITH ORAL PRESENTATION

Nome do Apresentador: Ana Claudia Garcia ROSA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Oncologia

Resumo: A 49-year-old brown-skinned patient sought dental care for a persistent tongue lesion noticed three months prior, causing eating difficulties. The examination revealed a foul-smelling, erythematous, tumor-like lesion with ulceration and necrosis extending from the tongue to the oropharynx. An incisional biopsy with histopathological analysis revealed a proliferation of large cells with round nuclei, prominent nucleoli, and basophilic cytoplasm, suggesting lymphoproliferative neoplasia. The immunohistochemical analysis confirmed the diagnosis of diffuse large B-cell lymphoma, positive for BCL-2, CD20, CD45 LCA, c-Myc, Ki-67, and MUM 1. Referred to head and neck oncology followed by hematology-oncology, CT image examinations showed an isodense lesion in the tongue and oropharynx, extending to the neck, mediastinum, and abdomen, with no bone involvement. Lumbar puncture excluded CNS involvement. Chemotherapy led to lesion regression after the first session. Two months later, the patient continues treatment with a guarded prognosis due to the lesions extensive spread and delayed diagnosis.

Autor 1:  Ana Claudia Garcia ROSA

E-mail 1:  [email protected]

Autor 2:   José Afonso de ALMEIDA

E-mail 2:  [email protected]

Autor 3 :  Eduardo Zambaldi DA CRUZ

E-mail 3:  [email protected]

Autor 4:  Mariana Ercília Reis PINHEIRO

E-mail 4:  [email protected]

Autor 5:  Daniela da Motta RODRIGUES

E-mail 5:  [email protected]

Autor 6:  Fabiana Ferreira ALVES

E-mail 6:  [email protected]

Autor 7:  André Machado de SENNA

E-mail 7:  [email protected]