NUMERO: #20240561

Título: ASSOCIATION BETWEEN COCA CHEWING (ERYTHROXYLUM COCA) HABIT AND ORAL SQUAMOUS CELL CARCINOMA. A CASE-CONTROL STUDY

Nome do Apresentador: Ignacio MOLINA AVILA

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Previous reports hypothesized that chewing coca (CC) leaves, was associated with oral squamous cell carcinoma (OSCC). CC is a habit that shares many characteristics with the well-known practice of betel chewing. The aim of this study is to analyze the association between CC and OSCC among patients who attended a northern argentine public Hospital.
Methods: A case-control study was conducted (2013-2018). For each case of OSCC, three healthy control patients were included. Odds ratios were calculated to compare demographics, concurrent oral conditions, and other risk factors for OSCC.
Results: 62 cases and 180 controls were included, adjusted for sex and age. OSCC was significantly associated with tobacco use (27.4% vs. 9.4%, p = 0.001), CC (62.9% vs. 32.2%, p < 0.001), and poor oral condition (81.1% vs. 67.7%, p = 0.02). In the multivariate analysis, smoking (OR=2.77, 95% CI 1.23-6.25, p=0.0139), CC (OR=2.98, 95% CI 1.58-5.63, p=0.0007), and poor oral condition (OR=3.1, 95% CI 1.62-5.85, p=0.0006) remained independently associated with OSCC.
Conclusion: CC could be considered a risk factor for oral cancer in a subset of Argentinean patients. Further studies are needed to validate our findings to elucidate the underlying pathways linking this habit to oral carcinogenesis.

Autor 1:  Ignacio MOLINA AVILA

E-mail 1:  [email protected]

Autor 2:   Juan Martin PIMENTEL

E-mail 2:  [email protected]

Autor 3 :  Eduardo David PIEMONTE

E-mail 3:  [email protected]

Autor 4:  Emilio BUSCHIAZZO

E-mail 4:  [email protected]

Autor 5:  Adriana ECHAZU

E-mail 5:  [email protected]

Autor 6:  Gerardo GILLIGAN

E-mail 6:  [email protected]