NUMERO: #20240183

Título: OPPORTUNISTIC DIAGNOSIS OF POLYMORPHOUS ADENOCARCINOMA OF THE PALATE IN AN ELDERLY PATIENT: A CASE REPORT

Nome do Apresentador: Sebastião Silvério de Sousa NETO

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: A 74-year-old female patient was referred for evaluation of an asymptomatic nodular lesion on the palate discovered during a routine dental examination. The intraoral examination revealed a 1cm telangiectatic nodule with fibroelastic consistency and normal colouration. The main clinical hypotheses included pleomorphic adenoma and mucoepidermoid carcinoma. A fine-needle aspiration biopsy was performed. Cell-block slides stained with hematoxylin and eosin, as well as exfoliative cytology stained with Papanicolaou and Panoptic, revealed basaloid epithelial cells arranged in a cribriform pattern. An incisional biopsy was performed, revealing fibrosis, scattered microcysts, and neoplastic cells with nuclear pleomorphism. Immunohistochemical tests showed: AE1/AE3+, CK7+, S100+, and SOX10+, and negativity for P63, Smooth Muscle Actin, and Vimentin. These findings favoured the diagnosis of polymorphous adenocarcinoma. Surgical resection with clear margins was conducted by a head and neck surgeon. Histopathological analysis confirmed the diagnosis. The patient has been under follow-up for 17 months, with no signs of recurrence.

Autor 1:  Sebastião Silvério de Sousa NETO

E-mail 1:  [email protected]

Autor 2:   Daniela Giraldo ROLDAN

E-mail 2:  [email protected]

Autor 3 :  Eder Gerardo SANTOS-LEITE

E-mail 3:  [email protected]

Autor 4:  Lucas Lacerda de SOUZA

E-mail 4:  [email protected]

Autor 5:  Alan Roger SANTOS-SILVA

E-mail 5:  [email protected]

Autor 6:  Pablo Agustin VARGAS

E-mail 6:  [email protected]

Autor 7:  Márcio Ajudarte Lopes

E-mail 7:  [email protected]