NUMERO: #20240176

Título: STEM CELLS AS A TARGET POTENTIAL FOR FUTURE INDIVIDUALIZED THERAPIES OF AMELOBLASTIC CARCINOMAS AND ODONTOGENIC CYSTS

Nome do Apresentador: Thais Garcia Souza VIDAL

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Patologia Oral

Resumo: OBJECTIVE: To explore the efficacy of stem cells in the individualized therapy of ameloblastic carcinomas (AC) and odontogenic cysts. STUDY DESIGN: A literature review was carried out in the PubMed, Web of Science, Scielo databases using the descriptors "Stem Cells", "Odontogenic Cysts", "Cell Differentiation". RESULT: From a total of 72 publications, 17 studies published between 2019 and 2023 were selected. Analyses revealed significant association between stem cells, biological behavior of odontogenic lesions (Ol) and the expression of stem cell markers. SOX2 has been shown to distinguish ACA or odontogenic keratocysts from ameloblastomas. Two types of mesenchymal stem cells were isolated from fibrous capsules of dentigerous cyst before and after marsupialization. These fibroblast-like colony-forming cells express CD44+, CD90+, CD31-, CD34-, CD45- markers and differentiate into osteoblast-like cells, adipocytes, and chondrocytes under induction.CONCLUSION: Stem cells show promising potential in the individualized treatment of degeneration in regions of AC and odontogenic cysts.

Autor 1:  Thais Garcia Souza VIDAL

E-mail 1:  [email protected]

Autor 2:   Luana Ferreira Apolinário

E-mail 2:  [email protected]

Autor 3 :  Kethyla Duarte Pimentel

E-mail 3:  [email protected]

Autor 4:  Dayane Keila Aprigio Costa

E-mail 4:  [email protected]

Autor 5:  Laryssa Nogueira Penido

E-mail 5:  [email protected]

Autor 6:  Peterson Rangel de Jesus

E-mail 6:  [email protected]

Autor 7:  Fabiana de Freitas Bombarda Nunes

E-mail 7:  [email protected]