NUMERO: #20240113

Título: LANGERHANS CELL HISTIOCYTOSIS, A CHALLENGE FOR EARLY DIAGNOSIS

Nome do Apresentador: Alicia Rumayor Piña

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Langerhans cell histiocytosis (LCH) is a rare disorder where abnormal Langerhans cells proliferate. The most common oral manifestation is palate ulceration, however bone involvement may also occur mimicking periodontal disease. Its diagnosis represents a challenge and not uncommonly LCH is discovered from the oral manifestations. A 31-year-old male was referred for evaluation of painful hard palate ulcers that had been present for 1 year. He was initially treated for periodontal disease and had a diagnosis of TUGSE in a previous biopsy. Clinical and radiographic examination showed gingival erythema and recession as well as generalized bone loss. An incisional biopsy revealed abundant histiocytes admixed with eosinophils. Immunohistochemistry was positive for S-100 and CD1a leading to a diagnosis of LCH. Further evaluation found lesions in the rectal mucosa, spleen, and secondary diabetes insipidus. The patient started chemotherapy with a protocol including vinblastine, but died from pulmonary septic shock seven months after diagnosis.

Autor 1:  Alicia Rumayor Piña

E-mail 1:  [email protected]

Autor 2:   Katya Pulido Díaz

E-mail 2:  [email protected]

Autor 3 :  Sergio Alberto Flores Alvarado

E-mail 3:  [email protected]

Autor 4:  José Eduardo Cruz López

E-mail 4:  [email protected]

Autor 5:  Gabriela Azaria Rodríguez Alvarado

E-mail 5:  [email protected]