NUMERO: #20240110

Título: CURRENT INSIGHTS INTO STRATEGIES TO OVERCOME TREATMENT RESISTANCE IN SALIVARY MUCOEPIDERMOID CARCINOMA: A SCOPING REVIEW

Nome do Apresentador: Maria Eduarda PÉREZ-DE-OLIVEIRA

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Patologia Oral

Resumo: Objective: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland cancer, accounting for 30-35% of salivary gland malignancies. There are no effective treatments for inoperable/disseminated cases and high-grade tumors usually exhibit resistance to conventional chemotherapy. Thus, the aim of this study is to review published data associated with tumor resistance in salivary MECs to guide future strategies to overcome this issue. Study design: This scoping review was conducted according to the PRISMA guidelines and involved a comprehensive search on PubMed, Scopus, Embase, and Web of Science, in addition to the gray literature. The selection of studies was performed in two phases by two reviewers independently. Results: Different signaling pathways were found associated with MEC cells resistance to chemotherapy or radiotherapy, particularly those associated with stemness or apoptotic events, such as mTOR, NFkB, p53, and MRP-1. Moreover, epigenetic events, including histone H3 acetylation and bromodomain proteins were also identified as deregulated events. Pharmacological disruption of these molecular events emerges as key strategies to overcome MECs cells resistance. Conclusions: Understanding the mechanisms involved in resistance to therapy, is essential to improve the survival and the quality of life of patients with MEC. This study was supported by FAPESP 2019/26676-7.

Autor 1:  Maria Eduarda PÉREZ-DE-OLIVEIRA

E-mail 1:  [email protected]

Autor 2:   Pablo Agustin VARGAS

E-mail 2:  [email protected]

Autor 3 :  Vivian Petersen WAGNER

E-mail 3:  [email protected]