NUMERO: #20240010

Título: Light-chain-restricted russell body oral mucositis: an immunohistochemical study

Nome do Apresentador: Larissa Witzel Silva Dos SANTOS

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Plasma cells containing Russell bodies (RBs), or Mott cells, can be observed when assessing non-neoplastic and neoplastic lesions. Relevantly, light-chain-restriction on immunohistochemistry is an important criterion to distinguish them. In the oral cavity, several chronic inflammatory lesions present not uncommonly plasma cell infiltration admixed with RBs; however, few cases previously reported highlight prominent and extensive presence of RBs. An 80-year-old woman was referred presenting a large ulcerative lesion on the dorsal surface of the tongue several months ago. After biopsy, a Mott cell-rich lymphoplasmacytic infiltrate was observed. By immunohistochemistry, light-chain-restricted Mott cells were evident. After literature review, RB gastritis/duodenitis containing monotypic immunoglobulin light-chain-restricted populations have been reported, with the current case expanding their clinicopathological spectrum.

Autor 1:  Larissa Witzel Silva Dos SANTOS

E-mail 1:  [email protected]

Autor 2:   Luana Stefanie Silvino Gonçalves

E-mail 2:  [email protected]

Autor 3 :  Karina Helen Martins

E-mail 3:  [email protected]

Autor 4:  Magdalena Raquel Torres Reyes

E-mail 4:  [email protected]

Autor 5:  Anderson Tangerino Ferreira da Silva

E-mail 5:  [email protected]

Autor 6:  Fernando Chahud

E-mail 6:  [email protected]

Autor 7:  Jorge Esquiche León

E-mail 7:  [email protected]