NUMERO: #20240004

Título: IN VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF KAEMPFEROL: A SYSTEMATIC REVIEW

Nome do Apresentador: Everton Freitas de MORAIS

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Oncologia

Resumo: Objectives: This systematic review aims to highlight the potential therapeutic effects of kaempferol (KMP) on different types of solid malignant tumors, discussing the pathways and molecular mechanisms regulated by KMP and highlighting its potential as a natural anticancer drug.
Study Design: Electronic searches were carried out in EMBASE, Medline/PubMed, Cochrane Collaboration Library, Science Direct, Scopus, and Google Scholar. Articles that evaluated the effects of KMP treatment on the biological behavior of malignant solid tumor cells were selected for the present systematic review.
Results: Searches were performed in EMBASE, Medline/PubMed, Cochrane Collaboration Library, Science Direct, Scopus, and Google Scholar. After the application of study criteria, 64 studies were included. In vitro experiments demonstrated that KMP exerts antitumor effects by controlling tumor cell cycle progression, proliferation, apoptosis, migration, and invasion, as well as by inhibiting angiogenesis. KMP was also able to inhibit important markers that regulate epithelial-mesenchymal transition and enhanced the sensitivity of cancer cells to traditional drugs used in chemotherapy, including cisplatin and 5-fluorouracil.
Conclusions: KMP is a promising therapeutic compound and its combination with current anticancer agents may potentially produce more effective and predictable results.
Funding: FAPESP 2022/00994-5 and 2022/08908-0.

Autor 1:  Everton Freitas de MORAIS

E-mail 1:  [email protected]

Autor 2:   Lilianny Querino Rocha de OLIVEIRA

E-mail 2:  [email protected]

Autor 3 :  Hannah Gil de Farias MORAIS

E-mail 3:  [email protected]

Autor 4:  Maurília Raquel de Souto MEDEIROS

E-mail 4:  [email protected]

Autor 5:  Roseana de Almeida FREITAS

E-mail 5:  [email protected]

Autor 6:  Camila de Oliveira Rodini PEGORARO

E-mail 6:  [email protected]

Autor 7:  Ricardo Della COLETTA

E-mail 7:  [email protected]