NUMERO: #20230980

Título: USE OF PHOTODYNAMIC THERAPY (PDT) DURING THE ORAL CARCINOGENESIS PROCESS - AN ANIMAL MODEL STUDY

Nome do Apresentador: Lauren Frenzel SCHUCH

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Objective: To assess if photodynamic treatment (PDT) affects the development of lesions during chemically induced oral carcinogenesis.
Study Design: 4NQO was administered to 40 male Wistar rats. The carcinogen was given systemically for 12 and 20 weeks at a dose of 25 ppm diluted in distilled water. The animals were divided into two groups: Control and PDT. PDT applications were made once every week beginning in week 0. A swab impregnated with 5-Aminolevuinic (5-ALA) acid solution was rubbed on the posterior region of tongue of the rats. Two hours after the application of 5-ALA, the same point was irradiated with a laser.
Results: All the animals from both groups developed lesions on the posterior dorsum of the tongue. The lesions began as white patches and, along the time, erosive lesions, nodule, and ulcers could be observed. Regarding histopathological diagnosis, at the end of 12 weeks, epithelial dysplasia was the most common diagnosis, whereas squamous cell carcinoma was the most frequent lesions in both groups at 20 weeks. Nonsignificant differences were observed between control and PDT groups.
Conclusion: PDT neither promotes nor prevents the development of oral lesions during the process of 4NQO-induced carcinogenesis.

Autor 1:  Lauren Frenzel SCHUCH

E-mail 1:  [email protected]

Autor 2:   Tuany Rafaeli SCHMIDT

E-mail 2:  [email protected]

Autor 3 :  Vivian Petersen WAGNER

E-mail 3:  [email protected]

Autor 4:  Rogerio Moraes CASTILHO

E-mail 4:  [email protected]

Autor 5:  Cristina KURACHI

E-mail 5:  [email protected]

Autor 6:  Pablo Agustin VARGAS

E-mail 6:  [email protected]

Autor 7:  Manoela Domingues MARTINS

E-mail 7:  [email protected]