NUMERO: #20220290

Título: IMMUNOEXPRESSION OF INTERLEUKINS 6, 17 AND 18 IN ORAL LICHEN PLANUS

Nome do Apresentador: Juliana de Noronha Santos NETTO

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: Studies focusing on the expression of interleukins (IL) in oral lichen planus (OLP) are scarce. Objective: to analyze the immunohistochemical expression of IL-6, IL-17 and IL-18 in OLP. Study design: Forty paraffin-embedded specimens diagnosed as OLP were selected and clinicopathological characteristics were retrieved. Immunohistochemical reactions against IL-6, IL-17 e IL-18 were performed. Results: Patients were mostly adults with no gender predilection. Lesions affected mostly the buccal mucosa (85%), gingiva (47%) and tongue (42%), being reticular in 14 patients (35%) and reticular and atrophic/erosive in 26 (65%). Hyperkeratosis was observed in 21 cases (53%), and exocytosis of T CD4+ and T CD8+ lymphocytes in, respectively, 17 (42%) and 30 (75%) cases. IL-6 was the most expressed IL both in epithelium and connective tissue. IL-17 expression was intense in the connective tissue from 40% of the cases. IL-18 expression was mild/moderate both in epithelium (40% of the cases) and connective tissue (45% of the cases). Exocytosis was associated with higher ILs expression and expression of IL-17 was higher in hyperkeratotic epithelium. Conclusion: expression of the studied ILs was associated with exocytosis of T CD4+ and T CD8+ lymphocytes and can be associated with the epithelial alterations encountered in OLP.
Support: CNPQ and FAPERJ

Autor 1:  Juliana de Noronha Santos NETTO

E-mail 1:  [email protected]

Autor 2:   Fábio Ramôa PIRES

E-mail 2:  [email protected]

Autor 3 :  Teresa Cristina Ribeiro Bartholomeu dos SANTOS

E-mail 3:  [email protected]

Autor 4:  Luciana Armada DIAS

E-mail 4:  [email protected]

Autor 5:  Ricardo Guimarães FISCHER

E-mail 5:  [email protected]