NUMERO: #20220273

Título: OROFACIAL MANIFESTATION OF SÉZARY SYNDROME: A TRICKY DIAGNOSIS

Nome do Apresentador: Carla Isabelly RODRIGUES-FERNANDES

Categoria do Trabalho: Apresentação Oral de Casos Clínicos (AOC)

Área Temática: Estomatologia

Resumo: A rare case of Sézary syndrome (SS) diagnosed in an Oral Medicine service is presented. A 54-year-old female presented a generalized stinging sensation associated with pruritus and erythema of the skin with 2 years of duration, which has been treated with antihistamine, corticosteroid, and hydrating creams without resolution. Extraoral examination showed a painful and hardened lymphadenopathy on the right supraclavicular region. Ultrasound-guided fine-needle aspiration biopsy did not detect abnormalities. The patient's skin was remarkably dry and thickened, with erythroderma, fissures, and ulcerations, especially on arms and legs. Perioral region presented severe peeling and angular cheilitis. Onychodystrophy was also observed. Immunophenotyping of peripheral blood revealed proliferation of undifferentiated T-cells and TCD4+ cells. PET/CT exam demonstrated multiple lymphadenopathies and bone marrow biopsy was negative for neoplastic cells. She was diagnosed with SS and is currently undergoing treatment with UVB phototherapy, methotrexate, doxepin, and folic acid, with partial regression of signs and symptoms.

Autor 1:  Carla Isabelly RODRIGUES-FERNANDES

E-mail 1:  [email protected]

Autor 2:   Iara Gonçalves de Aquino

E-mail 2:  [email protected]

Autor 3 :  Isabel Schausltz Pereira Faustino

E-mail 3:  [email protected]

Autor 4:  Mariana de Pauli Paglioni

E-mail 4:  [email protected]

Autor 5:  Pablo Agustin Vargas

E-mail 5:  [email protected]

Autor 6:  Márcio Ajudarte Lopes

E-mail 6:  [email protected]

Autor 7:  Alan Roger Santos-Silva

E-mail 7:  [email protected]