NUMERO: #20220224

Título: THE IMPACT OF THE METOTREXATO SEERIC DOSAGE ON THE INCIDENCE AND SEVERITY OF ORAL MUCOSITIS IN ONCOPEDIATRIC PATIENTS

Nome do Apresentador: Camilla Siqueira de AGUIAR

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Oncologia

Resumo: Objective: To present a study on the impact of Methoexact sectum (MTX) dosage on toxicity in oncopediatric patients. Study Design: The collection of demographic and current disease of the patients was collected, extracted from the medical records and dental follow-up records. The degrees of hematological toxicity were graded according to the National Cancer Institute (NCI). Results: In the present study, a higher incidence of hematological toxicity was observed in cycles that infused 5g/m², with neutropenia, anemia and thrombocytopenia being the most frequent. Considering patients who infused 2.5 g/m2 of MTX, 10 cycles had oral mucositis. The toxicity of cycles that made 5 g/m2 varied according to infusion time. As for toxicity in other sites, mucositis grades I and II were the most seen. There were 07 cycles that showed delay in the elimination of MTX at hour 42, however, most of these cycles showed creatinine elevation from baseline pre-infusion values and, in these cycles, there was a need for change in the rescue with Leucovorin (LCV), with mucositis grade II as the most prevalent in these cases. Conclusion: We can observe that the higher the MTX dosage, the higher the incidence and severity of oral mucositis.

Autor 1:  Camilla Siqueira de AGUIAR

E-mail 1:  [email protected]

Autor 2:   Bruno Luiz Ferreira da SILVA

E-mail 2:  [email protected]

Autor 3 :  Maria Gabriela Lima Barbosa MONTEIRO

E-mail 3:  [email protected]

Autor 4:  Fabiana Moura da Motta SILVEIRA

E-mail 4:  [email protected]

Autor 5:  Arnaldo de França CALDAS JÚNIOR

E-mail 5:  [email protected]

Autor 6:  Gustavo Pina GODOY

E-mail 6:  [email protected]