NUMERO: #20220220

Título: THE EFFECT OF TUMOR ACIDITY ON ANTITUMOR IMUNE RESPONSE - A SYSTEMATIC REVIEW.

Nome do Apresentador: Natalia Koerich LAUREANO

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Oncologia

Resumo: Inhibition of cell´s malignant transformation and progression relies, besides other factors, in an effective immune response.
This study aims to compile and discuss the mechanisms underlying how the presence of lactic acid and/or tumor acidity results in antitumor immune response inefficiency.
A systematic review was conducted according to PRISMA guidelines and registered at PROSPERO. The search was performed on PubMed and EMBASE and designed to identify all studies evaluating the effects of tumor-generated acidosis and/or acid lactic on immune response. Literature reviews, conference abstracts, and scientific articles not written in English were excluded.
9451 references were found, after reading abstracts/titles, 145 were selected for full-text reading, resulting in 102 selected. The main findings detected were: alteration in receptors, ligands, and adhesion molecules on immune cells; decreased cytotoxicity of effector cells; polarization of macrophages into M2 phenotype; disturbed maturation of monocytes; imbalanced cytokine production and secretion; decreased cell proliferation and motility; unsettled activation and cell function; distorted activation of signaling pathways.
The tumor microenvironment can change important key pathways on tumor development, and the neutralization of the tumor acidity would benefit the development of new immunotherapies.

Autor 1:  Natalia Koerich LAUREANO

E-mail 1:  [email protected]

Autor 2:   Bianca de Bem PRUNES

E-mail 2:  [email protected]

Autor 3 :  Julia Silveira NUNES

E-mail 3:  [email protected]

Autor 4:  Larissa Volfart ROCHA

E-mail 4:  [email protected]

Autor 5:  Fernanda VISIOLI

E-mail 5:  [email protected]