NUMERO: #20220176

Título: CEPHAELINE SENSITIZES CISPLATIN AND REDUCES ORAL SQUAMOUS CELL CARCINOMA CANCER STEM CELLS

Nome do Apresentador: Amanda Almeida LEITE

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Oncologia

Resumo: Objective: To evaluate the anticancer properties of Cephaeline on Oral Squamous Cell Carcinoma (OSCC) cell lines, including cancer stem cells (CSC) maintenance.
Study Design: SCC4, SCC9, and SCC25 OSCC cell lines were used. Cell viability was assessed by MTT. The presence of CSC was evaluated by tumorsphere formation. The histone acetylation (H3K9ac) status was determined by immunofluorescence staining.
Results: A single administration of Cephaeline disrupted CSC through tumorspheres reduction. Additionally, cephaeline impacted on histone acetylation status and in a concomitant therapy with CDDP reduces the concentration of CDDP required to achieve IC50 in two cell lines (SCC4 and SCC9).
Conclusion: Our findings suggest that Cephaeline have anti-cancer properties in OSCC, disrupting the ability of cancer cells to generate tumorspheres. Moreover, can may represent an adjunct therapy to conventional treatments for OSCC. In vivo studies are needed to validate these findings.
Funding: FAPESP 2016/05710-4

Autor 1:  Amanda Almeida LEITE

E-mail 1:  [email protected]

Autor 2:   Luan César da SILVA

E-mail 2:  [email protected]

Autor 3 :  Gabriell Bonifácio BORGATO

E-mail 3:  [email protected]

Autor 4:  Alan Roger SANTOS-SILVA

E-mail 4:  [email protected]

Autor 5:  Manoela Domingues MARTINS

E-mail 5:  [email protected]

Autor 6:  Marcio Ajudarte LOPES

E-mail 6:  [email protected]

Autor 7:  Pablo Agustin VARGAS

E-mail 7:  [email protected]