NUMERO: #20220170

Título: HISTOPATHOLOGICAL PARAMETERS REPORTED IN MICROINVASIVE ORAL SQUAMOUS CELL CARCINOMA: A SYSTEMATIC REVIEW

Nome do Apresentador: Cristina SALDIVIA-SIRACUSA

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: OBJECTIVE: To assess patterns of histopathological outcomes reported in microinvasive oral squamous cell carcinoma (OSCCmi) cases. STUDY DESIGN: An online search in major databases was performed without period restriction, and 2,024 publications in English, Spanish and Portuguese were obtained. After screening and eligibility, 4 studies were selected. The risk of bias was assessed using Joanna Briggs Institute Critical Appraisal Checklist. A descriptive synthesis was conducted. RESULTS: All 4 publications included were retrospective, reporting a total of 116 OSCCmi patients, with a male predominance (1.6:1) and a mean age of 55.9 years. The main parameters considered for microinvasion were tumor thickness (TT) (range 4-10mm) and depth of invasion (DOI) (range 0,02-5mm). Definition, cut-off values, and assessment of microscopic features were not standardized. Other relevant measures such as perineural or lymphovascular invasion and pattern of invasive front were barely described, and cytological/architectural characteristics were not pondered. CONCLUSION: TT and DOI are currently the primary histopathological criteria used to define OSCCmi. Nonetheless, the outcomes of this systematic review showed the absence of standardized quantitative parameters to render the diagnosis of incipient OSCC. Therefore, additional studies aiming to standardize histopathological outcomes to report OSCCmi are paramount.

Autor 1:  Cristina SALDIVIA-SIRACUSA

E-mail 1:  [email protected]

Autor 2:   Anna Luiza Damaceno ARAUJO

E-mail 2:  [email protected]

Autor 3 :  Pablo Agustin VARGAS

E-mail 3:  [email protected]

Autor 4:  Márcio Ajudarte LOPES

E-mail 4:  [email protected]

Autor 5:  Alan Roger SANTOS-SILVA

E-mail 5:  [email protected]