NUMERO: #20220164

Título: EXPRESSION OF MITOCHONDRIAL DYNAMIC MARKERS IN ADENOID CYSTIC CARCINOMA

Nome do Apresentador: Maria Sissa Pereira SANT´ANA

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: Objective: The aim of the study was to investigate the prognostic significance of mitochondrial dynamic markers in adenoid cystic carcinoma (AdCC). Study design: Fifty-seven formalin-fixed paraffin-embedded cases were retrieved and disposed in tissue microarray. Histological sections were submitted to immunohistochemical reactions against AMT, DRP1, FIS1, MFN1, MFN2 and OPA1 proteins. Clinical data were retrieved from the patients´ medical files, including specific and disease-free survival data. Results: It was observed that 50.9% of the cases were strongly positive for AMT and DRP1, and 49.1%, 21.1%, 22.8% and 24.6% strongly positive for FIS1, MFN1, MFN2 and OPA1, respectively. Reactions were observed in both epithelial and myoepithelial components of the tumour. The higher expression of MFN2 was associated with solid microscopic pattern (p = .016). DRP1 overexpression showed a trend towards a shorter overall survival (p = .054), while negative/weak OPA1 showed a trend towards a lower DFS (p=.051) in the univariate analysis, but no mitochondrial marker represented an independent prognostic determinant under multivariate analysis. Conclusion: Mitochondrial dynamics markers do not seem to carry a prognostic significance for AdCC patients, but these proteins may play an important role in its pathogenesis. Support: FAPEMIG, CAPES, CNPq.

Autor 1:  Maria Sissa Pereira SANT´ANA

E-mail 1:  [email protected]

Autor 2:   Cínthia Verónica Bardález López DE CÁCERES

E-mail 2: 

Autor 3 :  Lucas Ambrosio LIMA

E-mail 3: 

Autor 4:  Ciro Dantas SOARES

E-mail 4: 

Autor 5:  Ricardo Santiago GOMEZ

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Autor 6:  Pablo Agustin VARGAS

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Autor 7:  Felipe Paiva FONSECA

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