NUMERO: #20220148

Título: Low-Grade Myofibroblastic Sarcoma of the oral cavity

Nome do Apresentador: Daniela Giraldo ROLDAN

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: Low-grade myofibroblastic sarcoma (LGMS) represents a distinct atypical myofibroblastic tumor of deep soft tissues, with a head and neck predilection. It has a variety of appearances, from fasciitis-like or fibromatosis-like to fibrosarcoma-like. Here, a series of four cases from two different institutions is shown, represented by 2 men and 2 women presenting a nodular lesion, with equal distribution in maxilla and mandibula. Microscopically, all cases showed a neoplasm formed by oval to spindle cells in a fibrous stroma with myxoid and dense areas, some atypical mitoses, and prominent nucleoli. These findings suggested a mesenchymal tumor. An immunohistochemical panel was performed, which showed positivity for smooth muscle actin (3 of 4 cases), HHF35 (2 of 4 cases), β-catenin (3 of 3 cases), calponin (2 of 4 cases) and Ki-67 (range 5-40%). H-Caldesmon was negative for all cases, demonstrating myofibroblastic and smooth muscle differentiation.The diagnosis of LGMS was confirmed in all cases.

Autor 1:  Daniela Giraldo ROLDAN

E-mail 1:  [email protected]

Autor 2:   Brendo Vinícius Rodrigues LOUREDO

E-mail 2:  [email protected]

Autor 3 :  Ana Luiza Oliveira Corrêa ROZA

E-mail 3:  [email protected]

Autor 4:  Carla Isabelly Rodrigues-FERNANDES

E-mail 4:  [email protected]

Autor 5:  Alan Roger dos Santos-Silva

E-mail 5:  [email protected]

Autor 6:  Hélder Antônio Rebelo Pontes

E-mail 6:  [email protected]

Autor 7:  Pablo Agustin Vargas.

E-mail 7:  [email protected]