NUMERO: #20220141

Título: ALDH1 EXPRESSION IN LAMINA PROPRIA OF LICHEN PLANUS, LICHENOID REACTION, LEUCOPLAKIA AND INFLAMMATORY PROCESS

Nome do Apresentador: Daniela Pereira MEIRELLES

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: Objective: To evaluate the differences in ALDH1 expression in lamina propria of oral lichen planus (OLP), oral lichenoid reaction (OLR), leucoplakia, and nonspecific chronic inflammatory process (NCIP). Study Design: were selected 16 samples from each group. The OLP and OLR followed van der Meij and van der Waal criteria, the leucoplakia and NCIP presented subepithelial chronic inflammatory infiltrate. The ALDH1 expression of the samples was investigated by immunohistochemistry. Were evaluated the percentage of positive cells in the selected fields from the lamina propria, which were categorized in 1 to 3. The final score from each sample was defined as the fields' mean score. Only the cells located at the inflammatory infiltrate were considered.
Results: the OLP presented a higher median expression of ALDH1 in lamina propria (2.00) than RLO (1.25; p=0.012), leucoplakia (1.32; p=0.027), and NCIP (1.15; p=0.005). Moreover, in 4 RLO samples (25.0%), 6 leucoplakia (37.5%), and 5 NCIP (31.25%), all the evaluated fields showed less than 10% of the cells expressing ALDH1. In OLP this event did not occur. Conclusion: the ALDH1 expression in lamina propria was higher in OLP cases, raising the hypothesis that this protein is involved in an autoimmune response.
Acknowledgment: FAPEMIG

Autor 1:  Daniela Pereira MEIRELLES

E-mail 1:  [email protected]

Autor 2:   Michelle Danielle Porto MATIAS

E-mail 2:  [email protected]

Autor 3 :  Adriana Aparecida Silva DA COSTA

E-mail 3:  [email protected]

Autor 4:  Thalita Soares TAVARES

E-mail 4:  [email protected]

Autor 5:  Karine Duarte da SILVA

E-mail 5:  [email protected]

Autor 6:  Maria Cássia Ferreira de AGUIAR

E-mail 6:  [email protected]