NUMERO: #20220113

Título: AMELOBLASTIC CARCINOMA AND MALIGNANT AMELOBLASTOMA: A SYSTEMATIC REVIEW OF THE CASES REPORTED IN THE LITERATURE

Nome do Apresentador: Roberta Rayra MARTINS-CHAVES

Categoria do Trabalho: Apresentação Oral de Pôster de Revisões Narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: To compare clinicopathologic features and survival rate of the two malignant variants of ameloblastoma: ameloblastic carcinoma (AC) and malignant ameloblastoma (MA)

Methods: An electronic search was undertaken in August 2020. Eligibility criteria included publications having sufficient clinicopathological information to confirm the diagnosis.

Results: A total of 83 publications and 128 cases were included. Patients with AC were on average older than those with MA (49.6 ± 20.6 and 31.7 ± 14.6, respectively). Both tumours were prevalent in the mandible of male individuals. Metastases were reported in 19/71 cases of AC and all MA, mainly affecting the lung. The mean time until metastasis was longer for MA (165.4 ± 142.7) than for AC (75.2 ± 151.3) months. The surgical excision was the first-line therapy for both tumours followed by radiotherapy as a complementary treatment. Although a slightly increased mortality rate was observed in MA, the difference in the estimated cumulative survival between patients AC and MA was not statistically significant (p = 0.116; log-rank test).

Conclusion: AC and MA shared some clinicopathological similarities, but further studies are necessary to delineate if they are different spectrums of the same malignant neoplasm or distinct pathological entities.

Autor 1:  Roberta Rayra MARTINS-CHAVES

E-mail 1:  [email protected]

Autor 2:   Bruno Ramos CHRCANOVIC

E-mail 2:  [email protected]

Autor 3 :  Flávia Sirotheau Correa PONTES

E-mail 3:  [email protected]

Autor 4:  Hélder Antônio Rebelo PONTES

E-mail 4:  [email protected]

Autor 5:  Felipe Paiva FONSECA

E-mail 5:  [email protected]

Autor 6:  Ricardo Santiago GOMEZ

E-mail 6:  [email protected]