NUMERO: #20220110

Título: EFFICACY OF DIFFERENT TREATMENTS FOR BURNING MOUTH SYNDROME: NETWORK META-ANALYSIS USING MINIMALLY CONTEXTUALIZED APPROA

Nome do Apresentador: Rachel Alvarenga BRANT

Categoria do Trabalho: Apresentação Oral de Pôster de Revisões Narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: the aim of this systematic review of randomized controlled trials (RCTs) was to assess the effectiveness of treatments for pain relief of burning mouth syndrome (BMS). Study Design: five databases and grey literature were searched, and the reference lists of included studies were hand searched. Independent reviewers selected studies, extracted data, and assessed risk of bias (RoB 2.0). The main outcome was pain relief. For the network meta-analysis (NMA), four comparable interventions were grouped into different geometries to ensure the transitivity assumption: laser, alpha lipoic acid (ALA), phytotherapics, and anxiolytics/antidepressants. The certainty of evidence was assessed using the GRADE approach for NMA with GRADE minimally contextualized framework. Results: the anxiolytic (clonazepam) probably reduces pain of BMS when compared to placebo (MD: -1.97; 95% CI: -2.31; -1.64; moderate certainty). Although laser, ALA, phytoterapics showed superiority when compared to placebo, the certainty was low or very low. Conclusion: among all tested treatments, only clonazepan is likely to reduce pain of BMS when compared to placebo. The majority of the other treatments had low and very low certainty, mainly due to imprecision and indirectness. More RCTs comparing treatments against placebo are encouraged to confirm the evidence.
Apoio: CAPES (bolsa mestrado)

Autor 1:  Rachel Alvarenga BRANT

E-mail 1:  [email protected]

Autor 2:   Fernando Oliveira COSTA

E-mail 2:  [email protected]

Autor 3 :  Gustavo Henrique de Mattos PEREIRA

E-mail 3:  [email protected]

Autor 4:  Rafael Paschoal Esteves LIMA

E-mail 4:  [email protected]

Autor 5:  Fernanda Vieira BELÉM

E-mail 5:  [email protected]

Autor 6:  Ricardo Santiago GOMEZ

E-mail 6:  [email protected]

Autor 7:  Carolina Castro MARTINS

E-mail 7:  [email protected]