NUMERO: #20220103

Título: Clinical, morphological and immunohistochemical analysis of head and neck rhabdomyosarcomas in pediatric patients: an in

Nome do Apresentador: Karen Domínguez GALLAGHER

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: Rhabdomyosarcoma is the most common soft tissue sarcoma in the pediatric population and about 40% of cases affect the head and neck region. Objective: to analyze the clinicopathologic and immunohistochemical features of head and neck rhabdomyosarcomas (HNRMS) in pediatric patients from Brazil, Guatemala, Mexico, and South Africa. Study Design: thirty-eight pediatric HNRMS were obtained from six Oral Pathology services in 23 years. Clinicopathological and immunohistochemical data of all cases were reviewed. Results: Most patients were from Brazil and South Africa (12/38; 31.6%, each), ten (26.3%) were from Guatemala, and four (10.5%) were from Mexico. The mean age of patients was 7.6 ± 4.7 years (range 1-19 years) with a slight female predilection. Non-parameningeal tissues (47.4%) were affected most commonly, followed by parameningeal (36.8%) and orbit (13.2%). Microscopically, the most common subtype was embryonal 86.8% (33/38), followed by alveolar 13.2% (5/38). Almost all cases (92.1%; 35/38) were positive for at least two myogenic markers: Desmin, Myogenin, and Myo-D1. Moderate to high Ki-67 proliferation index was identified in most cases. Conclusion: Pediatric HNRMS from Brazil, Guatemala, Mexico, and South Africa are more frequently diagnosed in children <10 years old and present classic clinicopathologic and immunohistochemical features for each subtype.

Autor 1:  Karen Domínguez GALLAGHER

E-mail 1:  [email protected]

Autor 2:   Willie VAN HEERDEN

E-mail 2:  [email protected]

Autor 3 :  Roman CARLOS +

E-mail 3: 

Autor 4:  Hélder Antônio Rebelo PONTES

E-mail 4:  [email protected]

Autor 5:  Lara Maria Alencar Ramos INNOCENTINI

E-mail 5:  [email protected]

Autor 6:  Mário José ROMAÑACH

E-mail 6:  [email protected]

Autor 7:  Alan Roger SANTOS-SILVA

E-mail 7:  [email protected]