NUMERO: #20220098

Título: OSTEOLYSIS OF THE MANDIBLE AND PERIODONTITIS ASSOCIATED WITH RHEUMATOID ARTHRITIS AND METHOTREXATE

Nome do Apresentador: Hudson Geraldo Raña da Matta FONSECA

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Estomatologia

Resumo: The citrullination process is exaggerated in rheumatoid arthritis, leading to abnormal accumulation of citrulline. Antibodies are released, triggering an autoimmune inflammatory process. Methotrexate, an antimetabolite and antifolate drug, used in arthritis leads to myelosuppression favoring the appearance of opportunistic infections. Methotrexate therapy has side effects, which include oral manifestations. The objective of this report is to describe a case of periodontal disease with osteolysis of the mandible associated with rheumatoid arthritis and methotrexate therapy. A 38-year-old female, 38 years old presented with a history of tooth mobility. Radiographic examination showed horizontal bone loss exceeding the middle third of the roots, in addition to bone rarefaction throughout the body of the mandible. Fine needle aspiration and an excisional biopsy with curettage of one of the lesions were performed, which yielded an inconclusive report. In the imaging follow-up, bone neoformation was observed in the biopsied region.

Autor 1:  Hudson Geraldo Raña da Matta FONSECA

E-mail 1:  [email protected]

Autor 2:   Maria Luzia dos Santos Firmino Moraes

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Autor 3 :  Daniela Prata Tacchelli

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Autor 4:  Mariana Quirino Silveira Soares

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Autor 5:  Victor Angelo Martins Montalli

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Autor 6:  Marcelo Sperandio

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Autor 7:  Paulo de Camargo Moraes

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