NUMERO: #20220064

Título: PHOTODYNAMIC THERAPY IN THE MANAGEMENT OF ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL CANCER - AN OVERVIEW

Nome do Apresentador: Lauren Frenzel SCHUCH

Categoria do Trabalho: Apresentação Oral de Pôster de Revisões Narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: Summarize the effects and safety of photodynamic therapy (PDT) on oral potentially malignant disorder (OPMD) and oral squamous cell carcinoma (OSCC).
Study Design: An overview was conducted based on PRISMA 2020 statement. Electronic searches without publication date restriction were made in five databases.
Results: Twenty-eight studies were included. Of them, 22 articles investigated only OPMDs - with oral lichen planus (OLP) and actinic cheilitis being the most frequent. Three articles focused on OSCC, while the other three covered OPMDs and OSCC. Methodologies used in the studies were heterogeneous. In this sense, 14 different types of photosensitizers were described. Moreover, PDT parameters showed laser wavelength, power density, and irradiation duration was 320-670 nm, 10-12000 mW/cm2, and 0.5-150 minutes, respectively. Concerning lesion response, 85.9% OSCC presented complete response, while 14.1% showed no resolution. Regarding OPMDs, erithroplakia/leukoeritrhoplakia had best response. Still, OLP had partial or no response in almost 75% cases.
Conclusion: PDT depends on lesion type and parameters used. The disparities in the results could be attributed to the different methodologies. Although the evidence demonstrated in the present overview suggested that PDT has effective response in OPMDs and OSCC, these findings need to be careful interpreted.

Autor 1:  Lauren Frenzel SCHUCH

E-mail 1:  [email protected]

Autor 2:   Laura Borges KIRSCHNICK

E-mail 2:  [email protected]

Autor 3 :  Tuany Rafaeli SCHMIDT

E-mail 3:  [email protected]

Autor 4:  Marcio Ajudarte LOPES

E-mail 4:  [email protected]

Autor 5:  Marco Antonio Trevizani MARTINS

E-mail 5:  [email protected]

Autor 6:  Alan Roger SANTOS-SILVA

E-mail 6:  [email protected]

Autor 7:  Manoela Domingues MARTINS

E-mail 7:  [email protected]