NUMERO: #20220059

Título: RADIOTHERAPY SIMULATION METHODS UTILIZED IN LABORATORY STUDIES OF RADIATION DAMAGE TO THE DENTITION: A SYSTEMATIC REVIEW

Nome do Apresentador: Alan Roger SANTOS-SILVA

Categoria do Trabalho: Apresentação Oral de Pôster de Revisões Narrativas ou sistemáticas (PRN)

Área Temática: Oncologia

Resumo: Objective: to investigate the radiation simulation methods used in vitro and ex vivo studies to assess the direct effects of radiation on dental microhardness, chemical, and biochemical alterations. Study design: searches were performed in PubMed, Scopus, Embase, and grey literature. Preclinical studies that examined the effect of radiation on permanent teeth were included. We used the modified CONSORT checklist of items for reporting preclinical studies to assess the risk of bias. Results: 32 studies met the inclusion criteria. The average radiation dose of in vitro studies was 53 (±22) Gy and in ex vivo studies was 69 (±1) Gy. Twenty-two studies used five different fractionation schemes. Twenty-two of the included studies did not report the radiotherapy modality of those reporting, and 6 m-V was the energy most often utilized. Twenty studies used linear accelerators, and seven used Cobalt-60 with the source-surface-distance of radiation ranging from 1.5 to 100 cm. Distilled water was the storage solution for the dental structure used most reported. Conclusion: the heterogeneity between radiation simulation methods used in the laboratory studies such as radiation dose, radiotherapy modality, fractionation regime, and the storage solutions utilized limit the conclusion regarding the direct effect of radiation on dental microstructure changes.

Autor 1:  Alan Roger SANTOS-SILVA

E-mail 1:  [email protected]

Autor 2:   Caique Mariano PEDROSO

E-mail 2:  [email protected]

Autor 3 :  Ana Carolina Prado RIBEIRO

E-mail 3:  [email protected]

Autor 4:  Maria Eduarda PEREZ DE OLIVEIRA

E-mail 4:  [email protected]

Autor 5:  Ana Gabriela Costa NORMANDO

E-mail 5:  [email protected]

Autor 6:  Marcio Ajudarte LOPES

E-mail 6:  [email protected]

Autor 7:  Mario Fernando de GOES

E-mail 7:  [email protected]