NUMERO: #20220058

Título: PROGNOSTIC SIGNIFICANCE OF CD30 EXPRESSION IN DIFFUSE LARGE B-CELL LYMPHOMA: A SYSTEMATIC REVIEW WITH META-ANALYSIS

Nome do Apresentador: Carla Isabelly RODRIGUES-FERNANDES

Categoria do Trabalho: Apresentação Oral de Pôster de Revisões Narrativas ou sistemáticas (PRN)

Área Temática: Oncologia

Resumo: Objective: To determine the frequency of CD30 expression in DLBCL and its potential for prognostic determination. Study Design: A systematic review was performed, followed by a quantitative meta-analysis to assess the frequency of CD30 expression with positivity cut-off values of >0% and >20%, and to determine its association with clinicopathological features and patients´ survival. Results: Using a cut-off value >0%, we observed that 3.5%-59.1% of the cases were considered positive for CD30. There was a significant association of the protein expression with a lower number of extra-nodal sites affected by the neoplasm, with Ann Arbor advanced stage, the absence of B-symptoms, the lack of MYC and BCL2 translocations, and a lower ECOG performance. Using a cut-off value >20%, we observed that 2.5%-36.7% of the cases were considered positive for CD30, being significantly associated with a lower number of extra-nodal sites affected by the neoplasm, Ann Arbor stages III/IV, non-GCB tumours, the lack of MYC and BCL2 translocations, and a lower ECOG value. Conclusion: Despite variations in the cut-off values used to determine CD30 positivity in DLBCL, the expression of this protein seems to be associated with a higher survival rate and better prognosis.

Autor 1:  Carla Isabelly RODRIGUES-FERNANDES

E-mail 1:  [email protected]

Autor 2:   Lucas Guimarães Abreu

E-mail 2:  [email protected]

Autor 3 :  Danyel Elias da Cruz PEREZ

E-mail 3:  [email protected]

Autor 4:  Rogério de Oliveira GONDAK

E-mail 4:  [email protected]

Autor 5:  Peter A Brennan

E-mail 5:  [email protected]

Autor 6:  Pablo Agustin Vargas

E-mail 6:  [email protected]

Autor 7:  Felipe Paiva Fonseca

E-mail 7:  [email protected]