NUMERO: #20220051

Título: CLINICAL MANIFESTATIONS OF HEAD AND NECK CANCER IN PEDIATRICS

Nome do Apresentador: Paola Aristizabal ARBOLEDA

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Oncologia

Resumo: Objective: Clinical manifestations of pediatric head and neck cancer (PHNC) are often unspecific and may lead to delayed diagnosis. We aimed to describe clinical findings of PHNC diagnosed in a single Brazilian hospital
Study Design: Clinicopathological data, signs and symptoms, and patterns of misdiagnosis were collected from medical records over a 30-year period. All PHNC cases affecting patients aged 19-years and younger were interpreted by statistical and descriptive analysis.
Results: Of 253 PHNC cases included, 154 (60.9%) affected male patients and the mean age was 9.3 years. Burkitt lymphoma (23.7%), nasopharyngeal carcinoma (15.8%), and rhabdomyosarcoma (15.4%) were the most common histopathological types. Anatomical sites such as nasopharynx (28.9%), cervical/lymph node region (25.3%), and craniofacial bones (8.3%) were predominant. Significant associations between tumor histology and variables such as sex (p=0.022), age (p<0.0001), anatomical location (p<0.0001) tumor/swelling (p=0.034), pain (p=0.031), systemic/general manifestations (p=0.004), nasal/breathing alterations (p=0.012), orbital/ocular alterations (p<0.0001) were observed. Misdiagnosis such as tonsillitis, otitis, and abscess were frequent.
Conclusion: Due to the lack of specific clinical findings in PHNC, the suspicion of malignancy should be considered when the main signs and symptoms reported here appear and persist, in order to conduct a timely diagnosis.

Autor 1:  Paola Aristizabal ARBOLEDA

E-mail 1:  [email protected]

Autor 2:   Maria Eduarda Pérez-de-Oliveira

E-mail 2:  [email protected]

Autor 3 :  Iva Loureiro Hoffmann

E-mail 3:  [email protected]

Autor 4:  Izilda Aparecida Cardinalli

E-mail 4:  [email protected]

Autor 5:  Karen Patricia Dominguez Gallagher

E-mail 5:  [email protected]

Autor 6:  Regina Maria Holanda de Mendonça

E-mail 6:  [email protected]

Autor 7:  Alan Roger Santos-Silva

E-mail 7:  [email protected]