NUMERO: #20220045

Título: TWO GRADING SYSTEMS FOR ORAL EPITHELIAL DYSPLASIA IN ORAL POTENTIALLY MALIGNANT DISORDERS: A CLINICOPATHOLOGICAL STUDY

Nome do Apresentador: Nathalia de Almeida FREIRE

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Patologia Oral

Resumo: Objectives To classify oral epithelial dysplasia (OED) by the WHO and binary grading systems in oral potentially malignant disorders (OPMD), besides associating sociodemographic and histopathological and features of these OPMD.
Study design Records and slides of 65 cases compatible with the clinicopathological diagnosis of OPMD were evaluated for both classification systems and submitted to bivariate analysis.
Results Middle-aged white men, non-smokers and non-drinkers predominated. Smoking was associated with high-risk lesions by the binary system (p=0.036) and oral leukoplakia (p=0.003). The cases graded as mild-OED and severe-OED by the WHO system (85.7%) were reclassified as low-risk and high-risk respectively by the binary system. In contrast, 61.8% of moderate-OED cases were reclassified as low-risk for malignant transformation. Abnormal variation in cell size and shape, increased number and size of nucleoli, drop-shaped rete ridges, loss of epithelial cell cohesion and abnormally superficial mitotic figures were statistically significant (p<0.05) in both grading systems. Interestingly, cytological changes were significant in WHO system, whereas architectural changes were significant in binary system.
Conclusions These are important histopathological features and should be taken into consideration when grading OED. Smoking was strengthened by the binary system as a risk factor for developing oral leukoplakia and its progression to malignancy.

Fomento: CNPq

Autor 1:  Nathalia de Almeida FREIRE

E-mail 1:  [email protected]

Autor 2:   Ana Cristina Tetzner

E-mail 2:  [email protected]

Autor 3 :  Ana Flávia Schueler de Assumpção Leite

E-mail 3:  [email protected]

Autor 4:  Adriana Terezinha Neves Novellino Alves

E-mail 4:  [email protected]

Autor 5:  Luisa Aguirre Buexm

E-mail 5:  [email protected]

Autor 6:  Simone de Queiroz Chaves Lourenço

E-mail 6:  [email protected]