NUMERO: #20220034

Título: NUT-CARCINOMA INVOLVING TRIGEMINAL NERVE - A CASE REPORT

Nome do Apresentador: Fabio Luiz CORACIN

Categoria do Trabalho: Apresentação Oral de Casos Clínicos (AOC)

Área Temática: Patologia Oral

Resumo: NUT-carcinoma is a rare aggressive disease caused by BRD4/3‐NUT fusion which results in MYC upregulation. A 50-years-old male patient presented frontotemporal headache and paraesthesia, evolving with worsening headache, diplopia, ptosis and reduced visual acuity for at least 12 months. Clinical diagnosis was meningioma due to an expansive process in the right temporal fossa with hyperostosis and optic canal stenosis. Histological analysis revealed malignant neoplasm presenting cohesive blocks of basaloid cells with foci of abrupt keratinization and necrosis, with infiltration of dense connective tissue and bone marrow. Immunohistochemistry was positive to EMA, P63, INI1(retained), AE1/AE3, CK5/6, CK8-18, CD117 and NUT. In addition, Ki-67 was positive in 80% of the neoplasia. Therefore, the final diagnosis was NUT carcinoma. The patient is still alive until the last follow-up. This case highlights the importance of considering NUT-carcinoma in the provisional diagnosis for undifferentiated or poorly differentiated neoplasms and immunohistochemistry can aid diagnosis.

Autor 1:  Fabio Luiz CORACIN

E-mail 1:  [email protected]

Autor 2:   Victor Tieghi Neto

E-mail 2:  [email protected]

Autor 3 :  Gustavo Ramos Teixeira

E-mail 3:  [email protected]

Autor 4:  Daniele Moraes Losada

E-mail 4:  [email protected]

Autor 5:  Justin A Bishop

E-mail 5:  [email protected]

Autor 6:  Carlos Afonso Clara

E-mail 6:  [email protected]

Autor 7:  Gabriel Augusto Limone

E-mail 7:  [email protected]