NUMERO: #20220022

Título: DIGITAL BIOMARKER 2D:4D AS A PREDICTOR OF CANCER: A SYSTEMATIC REVIEW

Nome do Apresentador: Célia Márcia Fernandes MAIA

Categoria do Trabalho: Apresentação Oral de Pôster de Revisões Narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: The aim of this study is to analyze and discuss the association between 2D:4D and cancer through a systematic review of the published literature.
Study design: This review was performed according to the criteria recommended for the systematic review of the PRISMA Statement. Twenty-five articles were selected for the systematic review involving eleven types of cancer with 4,569 cases and 19,416 controls.
Results: Variations in the results of the association between 2D:4D and cancer were observed between studies, whether in those that evaluated the same or different types of cancer. The variant genes HOX, AR and LIN28b linked to carcinogenesis and correlated with the 2D:4D ratio, a putative marker for the action of these genes, may contribute to the investigation of etiologic factors in the screening of patients with susceptibility to the development of squamous cell carcinoma.
Conclusion: Findings from studies involving 2D:4D as a proxy for fetal hormone exposure should be interpreted with caution. Other studies with a more homogeneous methodology to better investigate the findings should be carried out.
Acknowledgments
Minas Gerais State Research Foundation - FAPEMIG, Brazil,
National Council for Scientific and Technological Development - CNPq, Brazil,
Coordination of Improvement of Higher Education Personnel (CAPES), Brazil

Autor 1:  Célia Márcia Fernandes MAIA

E-mail 1:  [email protected]

Autor 2:   Cláudia de Alvarenga Diniz Fonseca

E-mail 2:  [email protected]

Autor 3 :  Renata Angélica Ferreira de Oliveira

E-mail 3:  [email protected]

Autor 4:  Daniella Reis Barbosa Martelli

E-mail 4:  [email protected]

Autor 5:  Verônica Oliveira Dias

E-mail 5:  [email protected]

Autor 6:  Adriana Amaral Carvalho

E-mail 6:  [email protected]

Autor 7:  Hercílio Martelli Júnior

E-mail 7:  [email protected]