NUMERO: #20220003

Título: THE IMPACT OF ORAL AND OROPHARYNGEAL CANCER PATIENT'S MEDICAL PROFILE ON TREATMENT-RELATED TOXICITIES.

Nome do Apresentador: Ana Carolina Prado-Ribeiro

Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)

Área Temática: Odontologia hospitalar

Resumo: Objective: To characterize oral and oropharyngeal squamous cell carcinoma (OOPSCC) patients with dental needs before cancer treatment. Patient's pre-oncological treatment data, including medical and sociodemographic characteristics, and laboratory tests results, were correlated with treatment-related head and neck toxicities. Study Design: A prospective cohort study. Results: 110 patients were included. The most common comorbidities were hypertension, dyslipidemia and diabetes. C-reactive protein, hemoglobin, and hematocrit were the most altered tests results. Toxicities were progressive over time. There was a positive correlation (0.268) between number of medications and oral mucositis (OM) and a negative correlation (-0.257) between medications and dysgeusia. For OM, altered exams had significative P values: thyroxine (T4) and free thyroxine (FT4) starting at D15; calcium at D5/10/30; urea at D25/30/33-35; creatinine at D15/30; alkaline phosphatase at D20/25; syphilis at D15/30. Family income and housing were OM predictors. Oral candidiasis (OC) was associated with syphilis and HIV at D20. Conclusion: OOPSCC patients have several comorbidities and abnormal laboratory results. No dental treatment before cancer treatment resulted in adverse events. Laboratory findings of altered T4, FT4, urea, calcium, alkaline phosphatase, creatinine, and syphilis may be useful predictors of OM. Syphilis and HIV may also be predictors of OC secondary to OOPSCC treatment.

Autor 1:  Leticia Rodrigues-Oliveira

E-mail 1:  [email protected]

Autor 2:   Maria Cecília Querido de Oliveira

E-mail 2:  [email protected]

Autor 3 :  Natalia Rangel Palmier

E-mail 3:  [email protected]

Autor 4:  Luiz Alcino Gueiros

E-mail 4:  [email protected]

Autor 5:  Thaís Bianca Brandão

E-mail 5:  [email protected]

Autor 6:  Alan Roger Santos-Silva

E-mail 6:  [email protected]

Autor 7:  Ana Carolina Prado-Ribeiro

E-mail 7:  [email protected]