NUMERO: #20260587

Título: LOCAL OZONE THERAPY TO PREVENT MEDICATION-RELATED OSTEONECROSIS OF THE JAW IN A RODENT IMMEDIATE IMPLANT MODEL

Nome do Apresentador: Mateus TORRES-SILVA

Categoria do Trabalho: Pôster - Investigação Original (IO)

Área Temática: Áreas afins no caráter multidisciplinar

Resumo: Objective: To evaluate the effects of ozone therapy on peri-implant repair in rats treated with zoledronic acid (ZA). Study design: Sixty-four male Wistar rats were used, divided into four groups (n=16). All animals received six intravenous injections of ZA (0.035 mg/kg) at 15-day intervals. The animals underwent implant placement immediately after extraction of the first right mandibular molar, followed by the following therapies: ZOL - ZA treatment only; GG - gaseous ozone (60 µg/mL); GO - ozonized oil (0.1 mL); and GGO - gaseous ozone and ozonized oil. Ozone therapies were applied to the peri-implant mucosa every four days for four weeks. The animals were euthanized 28 days postoperatively for clinical, biomechanical, microtomographic, histological, and implant surface topographic analyses. Results: Groups GG and GGO showed lower severity in clinical staging (p<0.05). GG revealed a higher mean removal torque. Higher concentrations of calcium and phosphorus were detected in the GO and GG groups. All ozone-treated groups showed a higher percentage of total bone area, bone neoformation, epithelial coverage, vital bone area, and greater bone volume, although bone-to-implant contact was similar among groups. Conclusion: Local ozone therapy positively modulated peri-implant healing in an experimental model of osteonecrosis.

Funding: FAPESP (2024/11004-1)

Autor 1:  Mateus TORRES-SILVA

E-mail 1:  [email protected]

Autor 2:   Nicole Barroso Quintino de OLIVEIRA

E-mail 2:  [email protected]

Autor 3 :  Maria Eduarda de Freitas Santana OLIVEIRA

E-mail 3:  [email protected]

Autor 4:  Maísa PEREIRA-SILVA

E-mail 4:  [email protected]

Autor 5:  Ynara Maria Gomes de SOUSA

E-mail 5:  [email protected]

Autor 6:  Natália dos Santos SANCHES

E-mail 6:  [email protected]

Autor 7:  Francisley Ávila SOUZA

E-mail 7:  [email protected]