NUMERO: #20260448

Título: Oral and Gut Microbiome Profiles in Triplets Discordant for Autism Spectrum Disorder

Nome do Apresentador: Nathália Tuany DUARTE

Categoria do Trabalho: Pôster - Relato de Caso ou Série de Casos

Área Temática: Odontologia para pacientes especiais

Resumo: Autism Spectrum Disorder (ASD) has been associated with alterations in the human microbiome. However, the relative contributions of environmental and individual factors remain unclear. This case report evaluates oral and gut microbiome profiles in dizygotic triplets sharing similar environmental and dietary conditions, including one child with ASD and two neurotypical siblings. Clinical oral examination and 16S rRNA sequencing were performed. Although dominant bacterial phyla were similar across individuals, differences emerged in microbial diversity and composition. The child with ASD exhibited lower oral microbial diversity, increased dental biofilm accumulation, and a distinct microbial profile. Beta diversity analysis revealed greater dissimilarity between oral and gut microbiomes in this individual, suggesting altered microbial compartmentalization. One neurotypical sibling showed increased microbial diversity associated with mild gingival inflammation, possibly reflecting an early ecological shift toward dysbiosis. These findings suggest that individual factors influence microbiome organization even under shared environmental conditions.

Autor 1:  Nathália Tuany DUARTE

E-mail 1:  [email protected]

Autor 2:   Caroline Augusta BELO Faria

E-mail 2:  [email protected]

Autor 3 :  Fabiana Martins e MARTINS de Oliveira

E-mail 3:  [email protected]

Autor 4:  Franciane Mendes de OLIVEIRA

E-mail 4:  [email protected]

Autor 5:  Joyce Vanessa da Silva FONSECA

E-mail 5:  [email protected]

Autor 6:  Marina Helena Cury GALLOTTINI

E-mail 6:  [email protected]