NUMERO: #20260442

Título: IMMUNOEXPRESSION OF β-CATENIN, CK-19 AND BCL-2 IN CALCIFYING ODONTOGENIC CYST: EPITHELIAL AND BIOLOGICAL INSIGHTS

Nome do Apresentador: Camila Maria Belarmino Dos Santos

Categoria do Trabalho: Pôster - Investigação Original (IO)

Área Temática: Patologia Oral

Resumo: Objective: To investigate the pattern of immunoexpression for β-catenin, CK-19, and Bcl-2, correlating it with clinical and histopathological features of calcifying odontogenic cysts. Study design: Twenty COCs were analyzed for the immunoreactivity of β-catenin, cytokeratin-19 (CK-19), and Bcl-2. The evaluation considered the percentages of cytoplasmic and nuclear immunoexpression in epithelial and ghost cells. Results: Weak β-catenin immunoreactivity was observed in the basal and suprabasal layers of the lining epithelium in most cases. In contrast, intense immunoreactivity was observed in ghost cells. CK-19 showed strong expression in basal and suprabasal cells. In ghost cells, low staining was observed. Bcl-2 demonstrated strong expression in basal cells, with a variable pattern in suprabasal cells, ranging from weak to strong to absent, and was not detected in ghost cells. Conclusion: The findings suggest the involvement of β-catenin in the regulation of cell proliferation and differentiation processes in COC. The expression of CK-19 reinforces the presence of odontogenic epithelial differentiation, possibly related to an ameloblastic phenotype. Bcl-2 appears to be involved in maintaining cell viability in the epithelial proliferative compartment. Taken together, the results corroborate the current understanding of the World Health Organization, indicating a predominantly non-neoplastic behavior for this lesion.

Autor 1:  Camila Maria Belarmino Dos Santos

E-mail 1:  [email protected]

Autor 2:   Elton Fernandes Barros

E-mail 2:  [email protected]

Autor 3 :  Jefferson Lucas Mendes

E-mail 3:  [email protected]

Autor 4:  Hébel Cavalcanti Galvão

E-mail 4:  [email protected]

Autor 5:  Pollianna Muniz Alves

E-mail 5:  [email protected]

Autor 6:  Cassiano Francisco Weege Nonaka

E-mail 6:  [email protected]

Autor 7:  Manuel Antonio Gordón-Núñez

E-mail 7:  [email protected]