NUMERO: #20260342

Título: NANOENCAPSULATED CINNAMALDEHYDE AS AN ADJUVANT THERAPY FOR CHEMICALLY INDUCED ORAL SQUAMOUS CELL CARCINOMA OF THE TONGUE

Nome do Apresentador: Paulo Rogerio Ferreti BONAN

Categoria do Trabalho: Pôster - Investigação Original (IO)

Área Temática: Áreas afins no caráter multidisciplinar

Resumo: Objective: To evaluate the effect of polymeric nanocapsules containing cinnamaldehyde on chemically induced tongue oral squamous cell carcinoma in mice.

Study design: Experimental study involving development and physicochemical characterization of cinnamaldehyde-loaded polymeric nanocapsules. In vitro assays were performed using SCC9 oral squamous cell carcinoma cells and HaCaT keratinocytes to assess cytotoxicity, proliferation, and migration. In vivo analysis used a murine model of chemically induced tongue oral squamous cell carcinoma. Histopathological examination was performed with hematoxylin and eosin staining. Bioinformatics, molecular docking, and RT-qPCR were used to investigate molecular mechanisms associated with tumor progression.

Results: The nanocapsules showed a mean diameter of 257.2 nm. NC-CNM at 50 μg/mL exhibited cytotoxic activity against SCC9 cells, reducing proliferation and migratory capacity in vitro. In animals, NC-CNM at 50 mg/kg inhibited tumor invasion in the tongue and reduced MMP2 expression, a marker associated with extracellular matrix degradation and invasion, while also reinforcing its potential to modulate pathways related to tumor aggressiveness.

Conclusion: Nanoencapsulated cinnamaldehyde demonstrated promising antitumor activity and may represent an innovative adjuvant strategy for tongue oral squamous cell carcinoma treatment.

Autor 1:  Paulo Rogerio Ferreti BONAN

E-mail 1:  [email protected]

Autor 2:   Lorena dos Reis Pereira QUEIROZ

E-mail 2:  [email protected]

Autor 3 :  Quemuel Pereira da SILVA

E-mail 3:  [email protected]

Autor 4:  Alfredo Maurício Batista de PAULA

E-mail 4:  [email protected]

Autor 5:  Francisco Humberto Xavier JUNIOR

E-mail 5:  [email protected]

Autor 6:  Andre Luiz Sena GUIMARÃES

E-mail 6:  [email protected]