NUMERO: #20260335

Título: Oral Tongue Squamous Cell Carcinoma in Young Patients Without Risk Factors: A Paradigm Shift - A Case Series and Review

Nome do Apresentador: Júlia Nascimento SOUZA

Categoria do Trabalho: Pôster - Relato de Caso ou Série de Casos

Área Temática: Oncologia

Resumo: Oral squamous cell carcinoma (OSCC) is traditionally associated with older individuals exposed to tobacco and alcohol. However, recent evidence indicates a rising incidence among young patients without classical risk factors, suggesting a paradigm shift in disease epidemiology. This study presents a literature review combined with a case series of four young patients (aged 28-42 years; three females, one male) diagnosed with OSCC. Notably, all patients experienced diagnostic delays, as initial evaluations by healthcare professionals underestimated the possibility of malignancy due to the patients atypical clinical profile. All cases presented with regional metastasis at diagnosis and exhibited aggressive clinical behavior, including early recurrence after curative-intent treatment; also all four patients died during follow-up. Emerging evidence suggests that young-onset OSCC may represent a distinct biological entity, potentially associated with worse prognosis and unique molecular features.

Autor 1:  Júlia Nascimento SOUZA

E-mail 1:  [email protected]

Autor 2:   Kelen Christine do Nascimento SOUZA

E-mail 2:  [email protected]

Autor 3 :  Sindeval José da SILVA

E-mail 3:  [email protected]

Autor 4:  Jéssica Ribeiro DAMASCENO

E-mail 4:  [email protected]

Autor 5:  Paulo Rogério de FARIA

E-mail 5:  [email protected]

Autor 6:  Sérgio Vitorino CARDOSO

E-mail 6:  [email protected]

Autor 7:  Marilia Ferreira ANDRADE

E-mail 7:  [email protected]