NUMERO: #20260115

Título: Intraosseous undifferentiated sarcoma of the mandible: A challenging clinicopathological case

Nome do Apresentador: Jose Victor Duarte FRANCO

Categoria do Trabalho: Apresentação Oral - Relato de Caso ou Série de Casos

Área Temática: Patologia Oral

Resumo: Undifferentiated sarcoma represents a diagnosis of exclusion. The present report describes an 18-year-old male patient referred to a tertiary hospital due to a comminuted fracture of left hemimandible after a sports trauma. Radiographic examination revealed an extensive fracture with ill-defined borders and absence of cortical bone associated with the lesion. Incisional biopsy showed a proliferation of spindle cells with cellular and nuclear pleomorphism, atypical mitoses, and positivity exclusively for vimentin and SOX-9, with exclusion of other lineages such as neural and epithelial. A similar profile was observed upon analysis of the hemimandibulectomy specimen, where the cell proliferation index was established at 20-30% by Ki 67 and staged as pT1N0. Therefore, negativity for the remaining 27 antibodies tested, including epigenetic investigation of H3K27 trimethylation with preserved expression, corroborated the interpretation of undifferentiated sarcoma, making a worse prognosis less favorable. The patient is currently under follow-up at the reference oncology hospital.

Autor 1:  Jose Victor Duarte FRANCO

E-mail 1:  [email protected]

Autor 2:   Pietra Bezerra Prestes

E-mail 2:  [email protected]

Autor 3 :  Francisco Amadis Batista

E-mail 3:  [email protected]

Autor 4:  Jeconias Câmara

E-mail 4:  [email protected]

Autor 5:  Paulo Victor Mendes Penafort

E-mail 5:  [email protected]

Autor 6:  Pablo Agustin Vargas

E-mail 6:  [email protected]

Autor 7:  Tatiana Nayara Libório Kimura

E-mail 7:  [email protected]