NUMERO: #20250569

Título: SYSTEMIC LEVELS OF L-DOPA AND DOPAMINE AND THEIR ASSOCIATION WITH ANXIETY SYMPTOMS IN PATIENTS WITH ORAL LEUKOPLAKIA

Nome do Apresentador: Ana Lívia SANTOS-SOUSA

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Objective: This study aimed to evaluate the systemic levels of L-DOPA and dopamine in patients with oral leukoplakia and their association with anxiety symptoms. Study Design: A cross-sectional analysis was conducted in 32 patients diagnosed with oral leukoplakia. Sociodemographic, clinicopathological, and biobehavioral data were collected from medical records. Plasma concentrations of L-DOPA and dopamine were quantified using high-performance liquid chromatography with electrochemical detection (HPLC-ED). Anxiety symptoms were assessed using the Beck Anxiety Inventory (BAI).
Results: The mean plasma concentrations were 147.1 pg/mL for L-DOPA and 68.92 pg/mL for dopamine. Pearsons correlation analysis revealed no significant association between L-DOPA and dopamine levels (p > 0.05). Specific anxiety symptoms, including "fear of the worst happening" (p = 0.009), "tachycardia" (p = 0.031), and "nervousness" (p = 0.037), were significantly associated with elevated dopamine concentrations. Multivariate analysis identified "fear of the worst happening" as the only independent predictor of higher dopamine levels (β = -13.2, p = 0.009). Conclusion: These findings demonstrate an association between specific anxiety symptoms and increased systemic dopamine levels in patients with oral leukoplakia, suggesting a potential neurobiological link between psychological stress and dopaminergic activity in this population.

Autor 1:  Ana Lívia SANTOS-SOUSA

E-mail 1:  [email protected]

Autor 2:   Daniela Brito BASTOS

E-mail 2:  [email protected]

Autor 3 :  Bruna Amélia Moreira SARAFIM-COSTA

E-mail 3:  [email protected]

Autor 4:  Rodrigo YOKOTA

E-mail 4:  [email protected]

Autor 5:  Glauco Issamu MIHAYARA

E-mail 5:  [email protected]

Autor 6:  Dulce Elena CASARINI

E-mail 6:  [email protected]

Autor 7:  Daniel Galera BERNABÉ

E-mail 7:  [email protected]