NUMERO: #20250539

Título: ATYPICAL MALIGNANT GRANULAR CELL TUMOR OF THE MANDIBLE: CASE REPORT

Nome do Apresentador: Nara Rúbia Pereira de SIQUEIRA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Oncologia

Resumo: An 85-year-old male farmer with Parkinsons disease and palliative prostate cancer treatment developed a painful, bleeding mandibular tumor over six months. After tooth extraction for a presumed dental infection, the lesion doubled in size within three months. The patient had a 70-year history of heavy smoking and alcohol use, with 80% tobacco-related lung damage. Examination revealed cachexia, fixed submental and submandibular lymphadenopathy, and a 10 cm irregular, ulcerated mass involving the anterior mandible and floor of the mouth, with radiographic evidence of bone resorption. Initial suspicion of prostate metastasis was excluded by biopsy showing undifferentiated malignancy. CT scan demonstrated bilateral lymph node involvement without distant metastases. Immunohistochemistry confirmed Atypical Malignant Neural Granular Cell Tumor (S100+, NSE+, CD68+; negative for pan-cytokeratin, P40, 34BE12, SOX10, HMB-45, Melan-A, ALK1, and CD56). The patients death three months after diagnosis. This case highlights the importance of dental surgeon training for improving healthcare quality.

Autor 1:  Nara Rúbia Pereira de SIQUEIRA

E-mail 1:  [email protected]

Autor 2:   Hemilly Domiense ANDRADE

E-mail 2:  [email protected]

Autor 3 :  Jailton Gomes Amâncio da SILVA

E-mail 3:  [email protected]

Autor 4:  Victor Hugo Lopes de Oliveira MOREIRA

E-mail 4:  [email protected]

Autor 5:  Elismauro Francisco de MENDONÇA

E-mail 5:  [email protected]

Autor 6:  Rejane Faria RIBEIRO-ROTTA

E-mail 6:  [email protected]