NUMERO: #20250508

Título: Oral Manifestation of DRESS Syndrome: Case Report in a Hospitalized Patient

Nome do Apresentador: Mayara Medeiros Lima de OLIVEIRA

Categoria do Trabalho: Apresentação oral de casos clínicos (AOC)

Área Temática: Odontologia hospitalar

Resumo: Severe cutaneous adverse reactions are potentially fatal manifestations characterized by delayed-type hypersensitivity. Between them, the DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) stands out, frequently associated with anticonvulsants. This study reports the case of a 72-year-old black female diagnosed with a brain tumor using Phenytoin and Dexamethasone. After four weeks of using these medications, she presented fever, odynophagia, dyspnea, and skin rashes, progressing to respiratory failure. During hospitalization, she developed painful ulcers on the gums, lip, and lower lip mucosa, with a scaly and friable appearance. A biopsy revealed extensive epithelial necrosis, spongiosis, exocytosis, and intense inflammatory infiltrate mixed with intravascular eosinophilia. Laboratory tests indicated eosinophilia and elevated liver transaminases, contributing, together with the clinical history, to a diagnostic hypothesis compatible with DRESS. Systematic treatment was carried out with corticosteroid therapy and antihistamines. For the oral lesions, laser therapy (3J) was used daily, resulting in complete remission.

Autor 1:  Mayara Medeiros Lima de OLIVEIRA

E-mail 1:  [email protected]

Autor 2:   Ana Carla Saldanha GUASSO

E-mail 2:  [email protected]

Autor 3 :  Auto Mateus Pau-Ferro RODRIGUES

E-mail 3:  [email protected]

Autor 4:  Daniella Moraes ANTUNES

E-mail 4:  [email protected]

Autor 5:  Gleyson Kleber do AMARAL-SILVA

E-mail 5:  [email protected]

Autor 6:  Mario Eduardo BALDO

E-mail 6:  [email protected]

Autor 7:  Regina Maria RAFFAELE

E-mail 7:  [email protected]