NUMERO: #20250506

Título: MUCOCUTANEOUS LEISHMANIASIS IN AN IMMUNOSUPPRESSED PATIENT: A DIAGNOSTIC CHALLENGE

Nome do Apresentador: Mariana Andrade COSTA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Odontologia hospitalar

Resumo: Mucocutaneous leishmaniasis (MCL) is a severe infection that can be difficult to diagnose. The objective is to describe a case of MCL with exclusive oral lesions in an immunosuppressed patient. An 82-year-old woman was referred for evaluation of painful oral lesions. Granulomatous, bleeding lesions with ulcerated and necrotic areas involving the anterior maxilla were observed. The patient had myelodysplastic syndrome and a history of untreated self-limited cutaneous leishmaniasis 5 years ago. The initial biopsy showed lymphoplasmacytic infiltrate with granulomas, but no leishmania (L). PCR, immunohistochemistry, and all serologies and cultures were negative. A second biopsy maintained the same pattern. However, oval structures positive for anti-leishmania antibody were observed. A third biopsy showed positive PCR for leishmania. Lesions showed significant reduction after liposomal amphotericin B, and patient has been monitored. This case highlights the importance of medical history and the challenge of diagnosing MCL in the granulomatous phase in immunosuppressed patients.

Autor 1:  Mariana Andrade COSTA

E-mail 1:  [email protected]

Autor 2:   Tatiane Cristina FERRARI

E-mail 2:  [email protected]

Autor 3 :  Rodrigo Braz CAMPOS

E-mail 3:  [email protected]

Autor 4:  Jorge Esquiche LÉON

E-mail 4:  [email protected]

Autor 5:  Lara Maria Alencar Ramos INNOCENTINI

E-mail 5:  [email protected]

Autor 6:  Ana Laura Polizel Ranieri CUNHA

E-mail 6:  [email protected]

Autor 7:  Leandro Dorigan DE MACEDO

E-mail 7:  [email protected]