NUMERO: #20250498

Título: AGGRESSIVE CRANIOFACIAL OSTEOSARCOMA WITH PALATAL AND MAXILLARY INVOLVEMENT IN A YOUNG ADULT: A THERAPEUTIC CHALLENGE

Nome do Apresentador: Tayná Figueiredo MACIEL

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: A 33-year-old woman, passive smoker, presented with a painful palatal nodule without ulceration, associated with left nasal obstruction for five months. Oroscopy revealed a violaceous, multinodular fibrotic lesion affecting the left hard and soft palate, without cervical lymphadenopathy. CT scan showed a hypodense expansile mass in the left maxillary sinus, extending to the choanal region, palate, and paranasal walls. MRI confirmed a heterogeneous lesion with bone erosion in the maxilla, nasal septum, ethmoid sinuses, and left orbital floor. Endoscopic resection revealed a poorly differentiated malignant neoplasm with myxochondroid matrix, suggestive of osteosarcoma, and positive margins. Neoadjuvant chemotherapy with cisplatin and doxorubicin was initiated. Following multidisciplinary discussion, radical surgery was performed: total maxillectomy, left hemimandibulectomy, and regional flap reconstruction. The 12.5 × 9.4 × 8.9 cm specimen confirmed predominantly myxoid osteosarcoma with chondroblastic component. Immunohistochemistry: CD99+, S100−, Ki-67: 25-35%. Adjuvant chemotherapy was started. Patient remains under multidisciplinary follow-up.

Autor 1:  Tayná Figueiredo MACIEL

E-mail 1:  [email protected]

Autor 2:   Moisés Willian Aparecido GONÇALVES

E-mail 2:  [email protected]

Autor 3 :  Nívia Castro BINDA

E-mail 3:  [email protected]

Autor 4:  Erika Said Abu EGAL

E-mail 4:  [email protected]

Autor 5:  Carlos Takahiro CHONE

E-mail 5:  [email protected]

Autor 6:  Albina ALTEMANI

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]