NUMERO: #20250475

Título: Squamous Cell Carcinoma of the buccal mucosa: An aggressive case in an alcoholic non-smoker patient

Nome do Apresentador: Ivana de Sousa BRANDÃO

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: The buccal mucosa (BM) is a common site of squamous cell carcinoma (SCC) in Southeast Asia due to tobacco-chewing habits but is rare in Western populations. An 82-year-old normosystemic male, chronic alcohol consumer with no tobacco history, presented with oral soreness and discomfort. Intraoral exam revealed an endophytic, asymptomatic lesion with indurated borders on the right BM. Incisional biopsy confirmed moderately differentiated SCC with muscle invasion, keratin pearls, atypical mitoses, and contact with dysplastic surface epithelium. The lesion rapidly progressed into a symptomatic erythroleukoplastic nodule measuring 4 cm. The patient was referred for oncologic treatment. This case highlights the aggressive behavior of SCC in a non-traditional site and patient profile, emphasizing the potential role of chronic alcohol consumption-independently-in the pathogenesis and progression of oral SCC. It underscores the need to consider alternative risk factors and molecular or environmental influences, even in the absence of tobacco use.

Autor 1:  Ivana de Sousa BRANDÃO

E-mail 1:  [email protected]

Autor 2:   Gislayne Nunes de SIQUEIRA

E-mail 2:  [email protected]

Autor 3 :  Matheus Alves GABRIEL

E-mail 3:  [email protected]

Autor 4:  Erika Machado do Carmo ALBUQUERQUE

E-mail 4:  [email protected]

Autor 5:  Marcelo Bonifácio da Silva SAMPIERI

E-mail 5:  [email protected]

Autor 6:  Filipe Nobre CHAVES

E-mail 6:  [email protected]

Autor 7:  Denise Helen Imaculada Pereira de OLIVEIRA

E-mail 7:  [email protected]