NUMERO: #20250471

Título: A CASE OF OSTEOSARCOMA WITH LOCAL AND DISTANT RECURRENCE FOLLOWING SURGICAL AND CHEMOTHERAPEUTIC TREATMENT

Nome do Apresentador: Nívia Castro BINDA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: A 39-year-old man presented with a progressively enlarging exophytic lesion in mandibular region, measuring approximately 10 cm. Computed tomography revealed an expansive mass involving the body and ramus of the right mandible, with extension into adjacent structures. Histopathological analysis identified a malignant, infiltrative small cell mesenchymal neoplasm. Immunohistochemical evaluation demonstrated FLI1 positivity, suggestive of Ewing sarcoma. Chemotherapy was administered, without therapeutic response. Subsequently, the patient underwent a right segmental mandibulectomy with microsurgical reconstruction using a fibular free flap. Histopathological analysis of the resected specimen revealed osteosarcoma with a heterogeneous pattern, including osteoblastic/sclerosing and pleomorphic variants, as well as a focal area with round cell morphology. Postoperatively, the patient developed complications at the graft site, including exposure of the fixation plate, necessitating a new surgical intervention. Five months later, local recurrence and pulmonary metastasis developed. The current management consists of palliative chemotherapy and close monitoring of both local and metastatic lesions.

Autor 1:  Nívia Castro BINDA

E-mail 1:  [email protected]

Autor 2:   Maria Clara Falcão RIBEIRO-DE-ASSIS

E-mail 2:  [email protected]

Autor 3 :  Gustavo de Souza VIEIRA

E-mail 3:  [email protected]

Autor 4:  Tayná Figueiredo MACIEL

E-mail 4:  [email protected]

Autor 5:  Alfio José TINCANI

E-mail 5:  [email protected]

Autor 6:  Albina ALTEMANI

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]