NUMERO: #20250457

Título: Bone-predominant non-Hodgkin lymphoma involving mandible: a rare case report

Nome do Apresentador: Lucas Francisco Arruda MENDONÇA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Oncologia

Resumo: Bone-predominant non-Hodgkin lymphoma (NHL) is a rare and aggressive disease, and its differential diagnosis with other osteolytic conditions is often challenging. This report presents a case of NHL with mandibular involvement. A 57-year-old female patient was admitted with bone pain, edema in the left mandibular region, and hypercalcemia. Imaging revealed an expansile, osteolytic lesion in the left mandible (measuring approximately 3 cm), pathological fractures in the femur, and widespread skeletal involvement on PET-CT. Mandibular biopsy revealed large lymphoid cells with scant cytoplasm, granular chromatin, presence of 2-3 nucleoli, Ki-67 (90%), CD20+, MUMI+, BCL2+ and 6+, and C-MYC+. With the diagnosis of NHL-NE, it was completed VI R-CHOP. PET-CT scan of the partial restaging showed significant tumor reduction. Unfortunately, she passed away of unknown causes before final staging. This case highlights the crucial role of hospital-based dental professionals in the early detection and diagnosis of systemic malignancies with oral manifestations.

Autor 1:  Lucas Francisco Arruda MENDONÇA

E-mail 1:  [email protected]

Autor 2:   Mayara Sayuri Kamimura Akama

E-mail 2:  [email protected]

Autor 3 :  Hugo Figueiredo Carvalho

E-mail 3:  [email protected]

Autor 4:  Karina Alessandra Michelão Grecca Pieroni

E-mail 4:  [email protected]

Autor 5:  Joel Del Bel Pádua

E-mail 5:  [email protected]

Autor 6:  Maya Fernanda Manfrin Arnez

E-mail 6:  [email protected]

Autor 7:  Leandro Dorigan de Macedo

E-mail 7:  [email protected]